Knee Pain: When Are Medicines No Longer Enough? Persistent Knee discomfort can interfere with daily routines. Simple activities such as walking and standing may become uncomfortable. Many people manage symptoms with medicines, physiotherapy, and lifestyle changes. However, surgery may be considered when these treatments no longer provide enough relief. https://www.diigo.com/item/note/b2kvl/ej4i?k=6f69308c80c4d8a97b1f6206f93551ed