Orexins are neuro-modulatory peptides involved in the control of diverse physiological functions through interaction with two receptors. orexin-1 (OX1R) and orexin-2 (OX2R). Recent evidence in pre-clinical models points toward a putative dichotomic role of the two receptors. with OX2R predominantly involved in the regulation of the sleep/wake cycle and arousal. https://www.mamapaisa.com/product-category/frizz-dismiss-shampoo/