We have generated a novel monoclonal antibody targeting human FGFR1c (R1c mAb) that caused profound body weight and body fat loss in diet-induced obese mice due to decreased food intake (with energy expenditure unaltered). in turn improving glucose control. R1c mAb also caused weight loss in leptin-deficient ob/ob mice. leptin receptor-mutant db/db mice. https://www.roneverhart.com/Roosevelt/